Methanol 2.5 Ltr
17-DMAG, CAS 467214-21-7, is a more potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM).
Manufacturer: Merck
Catalog ID: 100069.2511
Stock: In Stock
Description
| Overview | A potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen), and displays excellent bioavailability and aqueous solubility. |
| Catalogue Number | 100069 |
| Brand Family | Calbiochem® |
| Synonyms | NSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG |
References
| References | Tian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317. Jez, J.M., et al. 2003. Chem. Biol. 10, 361. Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7. |
Product Information
| CAS number | 467214-21-7 |
| ATP Competitive | N |
| Form | Purple solid |
| Hill Formula | C₃₂H₄₈N₄O₈ • HCl |
| Chemical formula | C₃₂H₄₈N₄O₈ • HCl |
| Reversible | N |
Applications
| Application | 17-DMAG, CAS 467214-21-7, is a more potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM). |
Biological Information
| Primary Target | 17-DMAG |
| Primary Target IC<sub>50</sub> | GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen |
| Purity | ≥95% by TLC |
Physicochemical Information
| Cell permeable | N |
Storage and Shipping Information
| Ship Code | Blue Ice Only |
| Toxicity | Standard Handling |
| Storage | -20°C |
| Protect from Light | Protect from light |
| Do not freeze | Ok to freeze |
| Special Instructions | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
Packaging Information
| Packaged under inert gas | Packaged under inert gas |
